Author/Authors :
Gonzalez-Campora، نويسنده , , Ricardo and Davalos-Casanova، نويسنده , , Guillermo and Beato-Moreno، نويسنده , , Antonio and Luque، نويسنده , , Rafael J and Alvarez-Kindelan، نويسنده , , Jose and Requena، نويسنده , , Maria J. and Montironi، نويسنده , , Rodolfo and Lopez-Beltrلn، نويسنده , , Antonio، نويسنده ,
Abstract :
Whether apoptotic index [AI] and/or Ki-67 labeling index [Ki-67LI] add prognostic information in bladder cancer remains unclear. Mean AI and Ki-67 LI increased with grade and stage in 147 superficial bladder tumors. AI (>1.7%) correlated with tumor size, grade and proliferation. Ki-67 LI (>10%) correlated with higher grade and stage. Tumor size and Ki-67 LI were independent predictors of disease-free and progression-free survival, respectively. Tumor size, patientʹs age and tumorʹs recurrence predicted overall survival. We conclude that conventional clinical parameters and Ki-67 LI define risk groups of bladder tumors, while AI has limited value.
