Title of article
Inhibition of gastric cancer cells associated angiogenesis by 15d-prostaglandin J2 through the downregulation of angiopoietin-1
Author/Authors
Fu، نويسنده , , Yuan-Gen and Sung، نويسنده , , Joseph JY and Wu، نويسنده , , Kaichun and Bai، نويسنده , , Alfa H.C. and Chan، نويسنده , , Martin C.W. and Yu، نويسنده , , Jun and Fan، نويسنده , , Dai-ming and Leung، نويسنده , , Wai K.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
9
From page
246
To page
254
Abstract
Peroxisome proliferator-activated receptor gamma (PPARγ) ligands have been shown to inhibit angiogenesis. We showed that treatment with 15d-PGJ2, a PPARγ ligand, downregulate the expressions of angiopoietin-1 (Ang-1) in gastric cancer cells MKN45. The medium of MKN45 cells treated with 15d-PGJ2 significantly inhibited the migration and tube formation of human umbilical vein endothelial cells (HUVECs). Moreover, Matrigel plug assay revealed that 15d-PGJ2 reduced in vivo angiogenesis induced by MKN45 cells. These modulations were restored by the addition of recombinant Ang-1. Our findings supported that 15d-PGJ2 suppressed angiogenesis of gastric cancer cells by downregulation of Ang-1.
Keywords
Angiogenesis , angiopoietin , Gastric cancer , Peroxisome proliferators activated receptor
Journal title
Cancer Letters
Serial Year
2006
Journal title
Cancer Letters
Record number
1809935
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