Title of article
Activation of the hedgehog pathway in a subset of lung cancers
Author/Authors
Chi، نويسنده , , Sumin and Huang، نويسنده , , Shuhong and Li، نويسنده , , Chengxin and Zhang، نويسنده , , Xiaoli and He، نويسنده , , Nonggao and Bhutani، نويسنده , , Manoop S. and Jones، نويسنده , , Dennie and Castro، نويسنده , , Claudia Y. and Logrono، نويسنده , , Roberto and Haque، نويسنده , , Abida and Zwischenberger، نويسنده , , Joseph and Tyring، نويسنده , , Stephen K. and Zhang، نويسنده , , Hongwei and Xie، نويسنده , , Jingwu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
8
From page
53
To page
60
Abstract
Activation of the hedgehog pathway is reported in lung cancer, but its frequency remains unknown. We examine activation of this pathway in lung cancers by in situ hybridization and immunohistochemstry, and find that less than 10% of the tumors have elevated hedgehog target gene expression. We further identify a cell line NCI-H209 and two primary tumors with no detectable Su(Fu), a negative regulator of the pathway. Ectopic expression of Su(Fu) in NCI-H209 cells down-regulates hedgehog target gene expression and leads to inhibition of cell proliferation. These data indicate that activation of the hedgehog pathway is activated through Shh over-expression or Su(Fu) inactivation in only a subset of lung cancers.
Keywords
PTCH1 , Hedgehog , lung cancer , Gli1 , Su(Fu)
Journal title
Cancer Letters
Serial Year
2006
Journal title
Cancer Letters
Record number
1809958
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