Title of article
Gene-environment interactions between smoking and a haplotype of RAI, ASE-1 and ERCC1 polymorphisms among women in relation to risk of lung cancer in a population-based study
Author/Authors
Vogel، نويسنده , , Ulla and Sّrensen، نويسنده , , Mette E Hansen، نويسنده , , Rikke Dalgaard and Tjّnneland، نويسنده , , Anne and Overvad، نويسنده , , Kim R.W. Wallin، نويسنده , , Hهkan and Nexّ، نويسنده , , Bjّrn A. and Raaschou-Nielsen، نويسنده , , Ole، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
7
From page
159
To page
165
Abstract
Homozygous carriers of a haplotype consisting of ERCC1 Asn118AsnA, ASE-1 G-21AG, RAI IVS1 A4364GA are at increased risk of lung cancer especially among women.
we analyse for gene-environment interactions with the predefined haplotype in a case cohort study including 428 lung cancer cases and a comparison group of 800 persons, all from the prospective Diet, Cancer and Health cohort of 57,000 Danes.
h smoking intensity (>20 g tobacco/day), there was only additional risk of smoking intensity among women who were homozygous carriers of the haplotype (IRR=2.03; 95% CI: 1.10–3.73 per 5 additional g tobacco/day).
Keywords
lung cancer , apoptosis , Population-based , SNPs
Journal title
Cancer Letters
Serial Year
2007
Journal title
Cancer Letters
Record number
1810064
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