Author/Authors :
Subtil، نويسنده , , Clément and Guérin، نويسنده , , Eric and Schneider، نويسنده , , Anne and Chenard، نويسنده , , Marie-Pierre and Martin، نويسنده , , Elisabeth and Domon-Dell، نويسنده , , Claire and Duluc، نويسنده , , Isabelle and Brabletz، نويسنده , , Thomas and Kedinger، نويسنده , , Michèle and Duclos، نويسنده , , Bernard and Gaub، نويسنده , , Marie-Pierre and Freund، نويسنده , , Jean-Noël، نويسنده ,
Abstract :
The expression of the CDX2 gene, a crucial regulator of gut homeostasis, is altered in human colorectal cancers in parallel with de-differentiation. Here, we have investigated the chromosomal status of CDX2 in human sporadic colorectal cancers with the phenotype of chromosomal instability. Allelic imbalance determination showed frequent rearrangements at the CDX2 locus. The rearrangements correlated with CDX2 gene amplification, as assessed by quantitative PCR analysis. However, they were not predictive of the Cdx2 protein pattern. These data suggest that mechanisms other than structural alterations at the CDX2 locus account for the change of expression in colorectal cancers.
