Author/Authors :
Kapoor، نويسنده , , Neha and Sharma، نويسنده , , Anuj Kumar and Dwivedi، نويسنده , , Vishnu and Kumar، نويسنده , , Anoop and Pati، نويسنده , , Uttam and Misra، نويسنده , , Krishna، نويسنده ,
Abstract :
A deoxy 11-mer oligonucleotide 5′-GTTAGGGTTAG-3′, complementary to a repeat sequence of human telomerase RNA template has been linked through phosphate and a C-2 linker to a bioactive tetraglycine conjugate of curcumin, a well-known antitumor herbal spice component of turmeric. This molecule has been transfected into KB and HeLa cell lines and found to affect cell growth in the former. This DNA–curcumin–tetraglycine acts as a prodrug being targeted by antisense mechanism to telomerase.
Keywords :
Telomerase , Hela cells , Curcumin , Anticancer , KB cells
