Author/Authors :
Ruesga، نويسنده , , Mar?´a Teresa and Acha-Sagredo، نويسنده , , Amelia and Rodr?guez، نويسنده , , Mar?´a José and Aguirregaviria، نويسنده , , José Ignacio and Videgain، نويسنده , , Juan and Rodr?guez، نويسنده , , Carlos and Mart?nez de Pancorbo، نويسنده , , Mar?´a de los Angeles and Aguirre، نويسنده , , José Manuel، نويسنده ,
Abstract :
Aberrant promoter hypermethylation is common in oral squamous cell carcinoma (OSCC) and may be useful as a marker for cancer cells. The aim of our study was to assess whether the detection of hypermethylation of the promoter region of p16INK4a in oral cytological samples could be a marker in patients with risk of developing an OSCC. Hypermethylation was detected in 20% (29/145) of the cases analyzed. These findings provide further evidence that the inactivation of p16INK4a, due to methylation, is an early event in the carcinogenic pathway of OSCC.
Keywords :
p16INK4a , Hypermethylation , Cytology , Risk , ORAL CANCER
