Author/Authors :
Van den Abbeele، نويسنده , , Anske and De Corte، نويسنده , , Veerle and Van Impe، نويسنده , , Katrien and Bruyneel، نويسنده , , Erik and Boucherie، نويسنده , , Ciska and Bracke، نويسنده , , Marc and Vandekerckhove، نويسنده , , Joël and Gettemans، نويسنده , , Jan، نويسنده ,
Abstract :
Gelsolin and CapG are both actin binding proteins that modulate a variety of physiological processes by interacting differently with the actin cytoskeleton. Several studies suggest that overexpression of these proteins promotes invasion in vitro. In this study we explored the contribution of these proteins in human cancer cell invasion and motility. We show that down regulation of CapG or gelsolin in several types of cancer cells, including MDA-MB 231 and PC-3 cells, significantly reduces the invasive and motile properties of cells, as well as cell aggregation. These results point to a role for CapG and gelsolin as tumor activator.
Keywords :
CapG , siRNA , Invasion , cell aggregation , Cytoskeleton , Cancer cell , Gelsolin
