Title of article
Induction of cytotoxic T cell response against HCA661 positive cancer cells through activation with novel HLA-A∗0201 restricted epitopes
Author/Authors
Pang، نويسنده , , Paul Ha-Sang and Chan، نويسنده , , Kin-Tak and Tse، نويسنده , , Luigi Ying-Wai and Chan، نويسنده , , Ray Chun-Fai and Cheung، نويسنده , , Ying-Kit and Sin، نويسنده , , Fion Wan-Yee and Guo، نويسنده , , Zhi-Hong and Xie، نويسنده , , Yong، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
8
From page
178
To page
185
Abstract
HCA661 is a cancer–testis (CT) antigen frequently expressed in human hepatocellular carcinoma (HCC). To search for immunogenic peptides of HCA661, bioinformatics analysis and CD8+ T cell IFN-γ ELISPOT assay were employed, and two HLA-A∗0201 restricted peptides, H110 and H246, were identified. These two HCA661 peptides are naturally processed in dendritic cells (DCs) and when used for DCs loading, they are sufficient to prime autologous CD8+ T cells to elicit cytotoxic response against HCA661+ human cancer cells. The HCA661 peptides, H110 and H246, are hence attractive candidates for human cancer immunotherapy.
Keywords
HLA-A?0201 restricted epitope , immunotherapy , HCA661 , dendritic cell , T cell
Journal title
Cancer Letters
Serial Year
2007
Journal title
Cancer Letters
Record number
1810817
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