Author/Authors :
Lee، نويسنده , , Sang Hyub and Ryu، نويسنده , , Ji Kon and Lee، نويسنده , , Kyeung-Yeup and Woo، نويسنده , , Sang Myung and Park، نويسنده , , Joo Kyung and Yoo، نويسنده , , Ji Won and Kim، نويسنده , , Yong-Tae and Yoon، نويسنده , , Yong Bum، نويسنده ,
Abstract :
Apigenin is a dietary flavonoid possessing therapeutic potential against cancers. This study was designed to investigate whether combination therapy with gemcitabine and apigenin enhanced anti-tumor efficacy in pancreatic cancer. In vitro, the combination treatment resulted in more growth inhibition and apoptosis through the down-regulation of NF-κB activity with suppression of Akt activation in pancreatic cancer cell lines (MiaPaca-2, AsPC-1). In vivo, the combination therapy augmented tumor growth inhibition through the down-regulation of NF-κB activity with the suppression of Akt in tumor tissue. The combination of gemcitabine and apigenin enhanced anti-tumor efficacy through Akt and NF-κB activity suppression and apoptosis induction.
Keywords :
pancreatic cancer , Apigenin , Gemcitabine , Akt , NF-?B
