Author/Authors :
Novak-Hofer، نويسنده , , Ilse and Cohrs، نويسنده , , Susan and Grünberg، نويسنده , , Jürgen and Friedli، نويسنده , , Alexandra and Schlatter، نويسنده , , Monika C. and Pfeifer، نويسنده , , Marco and Altevogt، نويسنده , , Peter and Schubiger، نويسنده , , P. August Schubiger، نويسنده ,
Abstract :
Antibodies directed against the L1 cell adhesion protein inhibit growth of SKOV3ip human ovarian cancer cells in vitro and in vivo. Responses of SKOV3ip cells in vitro to anti-L1 mAb chCE7 and Genistein were investigated. Genistein potentiated the anti-proliferative and pro-apoptotic effects of chCE7 in SKOV3ip cells. A combination of mAb chCE7 and Genistein strongly reduced the sensitivity of p44/42 (Erk1,2) kinase, Src kinase and Akt kinase to extracellular stimulation with serum, Epidermal Growth Factor and Hepatocyte Growth Factor. The observed synergy of antibodies directed against L1 with Genistein could lead to a new therapeutic option for ovarian cancer.
Keywords :
SKOV3ip cells , L1-CAM , Genistein , Anti-L1 antibody chCE7
