Author/Authors :
Pezzolo، نويسنده , , Annalisa and Capra، نويسنده , , Valeria and Raso، نويسنده , , Alessandro and Morandi، نويسنده , , Fabio and Parodi، نويسنده , , Federica and Gambini، نويسنده , , Claudio and Nozza، نويسنده , , Paolo and Giangaspero، نويسنده , , Felice and Cama، نويسنده , , Armando and Pistoia، نويسنده , , Vito and Garrè، نويسنده , , Maria Luisa، نويسنده ,
Abstract :
Aim of this study was to search for novel chromosomal imbalances and potential prognostic markers in pediatric ependymoma.
DNA, obtained from 20 children with intracranial ependymoma (World Health Organization WHO grades II and III), was analyzed using metaphase-based comparative genomic hybridization (CGH) and fluorescent in situ hybridization (FISH).
vel copy number aberrations (CNAs) here identified are (i) 4q33-qter loss, (ii) 10q25.2–q26.3 gain, (iii) 3q23-qter losses, (iv) 18q22.2 loss, and (v) 19p13.1–p13.3 gain.
mbined presence of 6p22-pter and 13q14.3-qter losses predicted significantly reduced survival. Larger studies are warranted to validate these findings.
Keywords :
CGH , Ependymoma , Chromosomal imbalances , Fish , Infant brain tumors
