• Title of article

    Identification of novel chromosomal abnormalities and prognostic cytogenetics markers in intracranial pediatric ependymoma

  • Author/Authors

    Pezzolo، نويسنده , , Annalisa and Capra، نويسنده , , Valeria and Raso، نويسنده , , Alessandro and Morandi، نويسنده , , Fabio and Parodi، نويسنده , , Federica and Gambini، نويسنده , , Claudio and Nozza، نويسنده , , Paolo and Giangaspero، نويسنده , , Felice and Cama، نويسنده , , Armando and Pistoia، نويسنده , , Vito and Garrè، نويسنده , , Maria Luisa، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2008
  • Pages
    9
  • From page
    235
  • To page
    243
  • Abstract
    Aim of this study was to search for novel chromosomal imbalances and potential prognostic markers in pediatric ependymoma. DNA, obtained from 20 children with intracranial ependymoma (World Health Organization WHO grades II and III), was analyzed using metaphase-based comparative genomic hybridization (CGH) and fluorescent in situ hybridization (FISH). vel copy number aberrations (CNAs) here identified are (i) 4q33-qter loss, (ii) 10q25.2–q26.3 gain, (iii) 3q23-qter losses, (iv) 18q22.2 loss, and (v) 19p13.1–p13.3 gain. mbined presence of 6p22-pter and 13q14.3-qter losses predicted significantly reduced survival. Larger studies are warranted to validate these findings.
  • Keywords
    CGH , Ependymoma , Chromosomal imbalances , Fish , Infant brain tumors
  • Journal title
    Cancer Letters
  • Serial Year
    2008
  • Journal title
    Cancer Letters
  • Record number

    1811552

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1811552