Author/Authors :
Garcيa، نويسنده , , Vanesa and Garcيa، نويسنده , , José M. and Peٌa، نويسنده , , Cristina and Silva، نويسنده , , Javier and Domيnguez، نويسنده , , Gemma and Lorenzo، نويسنده , , Yolanda and Diaz، نويسنده , , Raquel and Espinosa، نويسنده , , Pablo and de Sola، نويسنده , , Javier Garcيa and Cantos، نويسنده , , Blanca and Bonilla، نويسنده , , Félix، نويسنده ,
Abstract :
We studied by real-time PCR cyclin D1 and thymidylate synthase (TS) mRNA in plasma as possible markers of clinical outcome in breast cancer. We observed poor outcome in patients with presence of cyclin D1 mRNA in good-prognosis groups, such as negative vascular invasion. Presence of both markers was associated with non-response to treatment after relapse. In patients treated with tamoxifen, a trend to significant relation between poor outcome and cyclin D1 mRNA was found. Cyclin D1 mRNA in plasma could identify patients with poor overall survival in good-prognosis groups and patients non-responsive to tamoxifen.
Keywords :
PLASMA , cyclin D1 , breast cancer , ts , Prognostic , MRNA
