Author/Authors :
Woo، نويسنده , , Janghee and Lee، نويسنده , , Juna and Chae، نويسنده , , Young Kwang and Kim، نويسنده , , Myoung Sook and Baek، نويسنده , , Jin Hyen and Park، نويسنده , , Jong Chul and Park، نويسنده , , Min Joo and Smith، نويسنده , , Ian M. and Trink، نويسنده , , Barry and Ratovitski، نويسنده , , Edward and Lee، نويسنده , , Taekyul and Park، نويسنده , , Bumsoo and Jang، نويسنده , , Se Jin and Soria، نويسنده , , Jean C. and Califano، نويسنده , , Joseph A. and Sidransky، نويسنده , , David and Moon، نويسنده , , Chulso، نويسنده ,
Abstract :
Overexpression of several aquaporins has been reported in different types of human cancer but the role of AQPs in human carcinogenesis has not yet been clearly defined. Here, we demonstrate that ectopic expression of human AQP5 (hAQP5), a water channel expressed in lung, salivary glands, and kidney, induces many phenotypic changes characteristic of transformation both in vitro and in vivo. Furthermore, the cell proliferative ability of AQP5 appears to be dependent upon the phosphorylation of a cAMP-protein kinase (PKA) consensus site located in a cytoplasmic loop of AQP5. In addition, phosphorylation of the PKA consensus site was found to be phosphorylated preferentially in tumors. These findings altogether indicate that hAQP5 plays an important role in human carcinogenesis and, furthermore, provide an attractive therapeutic target.
