Author/Authors :
Feng، نويسنده , , Yunxia and Zhang، نويسنده , , Jianzhong and Dai، نويسنده , , Liping and Zhang، نويسنده , , Jianying and Wang، نويسنده , , Peng and Zang، نويسنده , , Jing and Li، نويسنده , , Yuchun and Wang، نويسنده , , Kaijuan and Zhang، نويسنده ,
Abstract :
The purpose of this study was to test the associations about Helicobacter pylori infection and polymorphisms of IL-1B-31/-511 and IL-1RN VNTR polymorphism with gastric cancer in cases’ and controls’ family members from the areas of high cancer prevalence in China. IL-1B-511T and IL-1RN∗2 were associated with risks of gastric cancer. The association strength reduced with the relative degree decreasing. Such association was not found in the polymorphisms of IL-1B-31. But the haplotype analysis of IL-1B-511 and IL-1B-31 genotype could enhance the risks of gastric cancer. The positive H. pylori status could increase the risks of IL-1B to gastric cancer.
Keywords :
IL-1 , polymorphisms , H. pylori , Haplotype analysis , Gastric cancer
