Title of article
β-Catenin/TCF pathway upregulates STAT3 expression in human esophageal squamous cell carcinoma
Author/Authors
Yan، نويسنده , , Shuang and Zhou، نويسنده , , Cuiqi and Zhang، نويسنده , , Wei and Zhang، نويسنده , , Guo and Zhao، نويسنده , , Xuejian and Yang، نويسنده , , Shangbin and Wang، نويسنده , , Yihua and Lu، نويسنده , , Ning and Zhu، نويسنده , , Hongxia and Xu، نويسنده , , Ningzhi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
13
From page
85
To page
97
Abstract
Precise roles of β-catenin/TCF pathway involved in esophageal tumorigenesis remain elusive. Here we found STAT3 overexpression in esophageal cancer cells and tissues, and its overexpression in esophageal squamous cell carcinoma (ESCC) tissues correlated with β-catenin cytoplasmic/nuclear accumulation. A functional TCF binding element was detected in STAT3 promoter which specifically bound to TCF4. Transfected β-catenin induced STAT3 transcriptional activity dose-dependently, and also enhanced STAT3 mRNA and protein levels. These inductions were specifically abolished by dominant-negative TCF4. These results suggest that STAT3 is a target of β-catenin/TCF pathway and might participate in esophageal tumorigenesis.
Keywords
?-catenin/TCF , ESCC , Target gene , Overexpression , STAT3
Journal title
Cancer Letters
Serial Year
2008
Journal title
Cancer Letters
Record number
1813117
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