Author/Authors :
Frank ، نويسنده , , Bernd and Burwinkel، نويسنده , , Barbara and Bermejo، نويسنده , , Justo Lorenzo and Fِrsti، نويسنده , , Asta and Hemminki، نويسنده , , Kari and Houlston، نويسنده , , Richard and Mangold، نويسنده , , Elisabeth and Rahner، نويسنده , , Nils and Friedl، نويسنده , , Waltraut and Friedrichs، نويسنده , , Nicolaus and Buettner، نويسنده , , Reinhard and Engel، نويسنده , , Christoph and Loeffler، نويسنده , , Markus and Holinski-Feder، نويسنده , , Elke and Morak، نويسنده , , Monika and Keller، نويسنده , , Gisela and Schackert، نويسنده , , Hans K. and Krüger، نويسنده , , Stefan and Goecke، نويسنده , , Timm and Moeslein، نويسنده , , Gabriela and Kloor، نويسنده , , Matthias and Gebert، نويسنده , , Johannes and Kunstmann، نويسنده , , Erdmute and Schulmann، نويسنده , , Karsten and Rüschoff، نويسنده , , Josef and Propping، نويسنده , , Peter، نويسنده ,
Abstract :
Ten non-synonymous single nucleotide polymorphisms (nsSNPs), which were recently associated with colorectal cancer risk in a comprehensive, array based study (AKAP9 M463I, DKK3 G335R, AMPD1 Q12X, LIPC L356F, PSMB9 V32I, THBS1 N700S, CA6 S90G, ASCC3 C1995S, DHX36 S416C and CPA4 G303C) were re-evaluated in the present study based on 626 German familial non-HNPCC colorectal cancer patients and 736 healthy controls. No associations of any of the 10 nsSNPs with colorectal cancer could be replicated. The combined analyses indicated that further research based on additional independent samples is required.
