Author/Authors :
Salnikov، نويسنده , , Alexei V. and Kusumawidjaja، نويسنده , , Grace and Rausch، نويسنده , , Vanessa and Bruns، نويسنده , , Helge and Gross، نويسنده , , Wolfgang and Khamidjanov، نويسنده , , Akmal and Ryschich، نويسنده , , Eduard and Gebhard، نويسنده , , Martha-Maria and Moldenhauer، نويسنده , , Gerhard and Büchler، نويسنده , , Markus W. and Schemmer، نويسنده , , Peter and Herr، نويسنده , , Ingrid، نويسنده ,
Abstract :
Recent findings suggest that the presence of cancer stem cells could be linked with patients’ survival. We profiled suggested cancer stem cell markers in tissue specimens of hepatocellular carcinoma and colorectal carcinoma liver metastases. About 1% of cells co-expressed cancer stem cell antigens, but there was no correlation between the amount of CD133+, CD133+/CD44+ or CD133+/CD24− cells and the patients’ clinical–pathological status or with the cancer stem cell marker-positive cells localization. CD133+ and CD133− fractions of Huh7 cells did not differ in migratory properties. Therefore, presence of markers alone should be taken with caution as single prognostic parameters.
Keywords :
Cancer stem cells , Tumour-initiating cells , hepatocellular carcinoma , colorectal carcinoma , MIGRATION
