Title of article :
SOX7, down-regulated in colorectal cancer, induces apoptosis and inhibits proliferation of colorectal cancer cells
Author/Authors :
Zhang، نويسنده , , Yu and Huang، نويسنده , , Shuyan and Dong، نويسنده , , Wei and Li، نويسنده , , Lin and Feng، نويسنده , , Yunpeng and Pan، نويسنده , , Lina and Han، نويسنده , , Zhenkun and Wang، نويسنده , , Xiuli and Ren، نويسنده , , Guoling and Su، نويسنده , , Dongmei and Huang، نويسنده , , Baiqu and Lu، نويسنده , , Jun، نويسنده ,
Abstract :
The sex-determining region Y-box 7 (Sox7) is a member of high mobility group (HMG) transcription factor family, essential for embryonic development and endoderm differentiation. Deregulation of Wnt signaling pathway is a hallmark of colorectal cancer. Our results showed that the expression level of SOX7 was frequently down-regulated in human colorectal cancer cell lines and in primary colorectal tumor tissues, and the SOX7 silencing was partially due to the aberrant DNA methylation of the gene. Restoration of SOX7 induced colorectal cancer cell apoptosis, inhibited cell proliferation and colony formation. In addition, SOX7 efficiently suppressed β-catenin-mediated transcriptional activity.
Keywords :
SOX7 , Wnt pathway , Colorectal Cancer , DNA methylation , apoptosis
