Title of article
Highly homologous hS100A15 and hS100A7 proteins are distinctly expressed in normal breast tissue and breast cancer
Author/Authors
Wolf، نويسنده , , Ronald and Voscopoulos، نويسنده , , Christopher and Winston، نويسنده , , Jason and Dharamsi، نويسنده , , Alif and Goldsmith، نويسنده , , Paul and Gunsior، نويسنده , , Michele and Vonderhaar، نويسنده , , Barbara K. and Olson، نويسنده , , Melanie and Watson، نويسنده , , Peter H. and Yuspa، نويسنده , , Stuart H.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2009
Pages
7
From page
101
To page
107
Abstract
Human S100A7 (psoriasin) is considered a marker for specific stages of breast cancer. hS100A15 is almost identical to hS100A7 and difficult to discriminate. We developed specific probes to distinguish hS100A7 and hS100A15, and demonstrate their differential distribution in normal breast tissue. Further, hS100A7 and S100A15 transcripts are elevated in ER/PR negative breast cancers, but hS100A15 protein is detected in all cancer specimens while hS100A7 protein is sporadically expressed. The differential regulation, expression and distribution of hS100A7 and hS100A15 and their reported distinct functions are compelling reasons to discriminate among these proteins in normal breast and breast cancers.
Keywords
Mammary cancer , calcium binding proteins , S100 , psoriasis , myoepithelial cells
Journal title
Cancer Letters
Serial Year
2009
Journal title
Cancer Letters
Record number
1813544
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