Author/Authors :
Wolf، نويسنده , , Ronald and Voscopoulos، نويسنده , , Christopher and Winston، نويسنده , , Jason and Dharamsi، نويسنده , , Alif and Goldsmith، نويسنده , , Paul and Gunsior، نويسنده , , Michele and Vonderhaar، نويسنده , , Barbara K. and Olson، نويسنده , , Melanie and Watson، نويسنده , , Peter H. and Yuspa، نويسنده , , Stuart H.، نويسنده ,
Abstract :
Human S100A7 (psoriasin) is considered a marker for specific stages of breast cancer. hS100A15 is almost identical to hS100A7 and difficult to discriminate. We developed specific probes to distinguish hS100A7 and hS100A15, and demonstrate their differential distribution in normal breast tissue. Further, hS100A7 and S100A15 transcripts are elevated in ER/PR negative breast cancers, but hS100A15 protein is detected in all cancer specimens while hS100A7 protein is sporadically expressed. The differential regulation, expression and distribution of hS100A7 and hS100A15 and their reported distinct functions are compelling reasons to discriminate among these proteins in normal breast and breast cancers.
Keywords :
Mammary cancer , calcium binding proteins , S100 , psoriasis , myoepithelial cells
