Author/Authors :
Yuichi and Ayuzawa، نويسنده , , Rie and Doi، نويسنده , , Chiyo and Rachakatla، نويسنده , , Raja Shekar and Pyle، نويسنده , , Marla M. and Maurya، نويسنده , , Dharmendra Kumar and Troyer، نويسنده , , Deryl and Tamura، نويسنده , , Masaaki، نويسنده ,
Abstract :
The effect of un-engineered (naïve) human umbilical cord matrix stem cells (hUCMSC) on the metastatic growth of MDA 231 xenografts in SCID mouse lung was examined. Three weekly IV injections of 5 × 105 hUCMSC significantly attenuated MDA 231 tumor growth as compared to the saline-injected control. IV injected hUCMSC were detected only within tumors or in close proximity to the tumors. This in vivo result was corroborated by multiple in vitro studies such as colony assay in soft agar and [3H]-thymidine uptake. These results suggest that naïve hUCMSC may be a useful tool for cancer cytotherapy.
Keywords :
Human umbilical cord matrix stem cells , breast cancer , MDA 231 cells , xenografts , Colony assay
