Author/Authors :
Yamada، نويسنده , , Hiroya and Takano، نويسنده , , Toru and Ito، نويسنده , , Yasuhiro and Matsuzuka، نويسنده , , Fumio and Miya، نويسنده , , Akihiro and Kobayashi، نويسنده , , Kaoru and Yoshida، نويسنده , , Hiroshi C. Watanabe، نويسنده , , Mikio and Iwatani، نويسنده , , Yoshinori and Miyauchi، نويسنده , , Akira، نويسنده ,
Abstract :
Nestin is a maker that identifies stem cells in some adult tissues, and its expression is believed to relate to malignancy in cancer cells. In this study, we measured the expression levels of nestin mRNA in various kinds of thyroid tumor by the real-time quantitative reverse transcription-polymerase chain reaction. Unexpectedly, nestin mRNA was detected in almost all differentiated thyroid tumors and normal thyroid tissues, whereas extremely decreased expression was observed in anaplastic carcinomas, which are the most malignant of the thyroid follicular cell-derived tumors. These results suggest that nestin mRNA is a differentiation marker, and its expression does not relate to malignant characteristics in thyroid tumors.
Keywords :
Cancer stem cell , Gene expression , anaplastic thyroid carcinoma , Nestin , thyroid transcription factor-1
