Title of article :
Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells
Author/Authors :
Xavier، نويسنده , , Cristina P.R. and Lima، نويسنده , , Cristovao F. and Preto، نويسنده , , Ana and Seruca، نويسنده , , Raquel and Fernandes-Ferreira، نويسنده , , Manuel and Pereira-Wilson، نويسنده , , Cristina، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2009
Pages :
9
From page :
162
To page :
170
Abstract :
KRAS and BRAF mutations are frequent in colorectal carcinoma (CRC) and have the potential to activate proliferation and survival through MAPK/ERK and/or PI3K signalling pathways. Because diet is one of the most important determinants of CRC incidence and progression, we studied the effects of the dietary phytochemicals quercetin (Q), luteolin (L) and ursolic acid (UA) on cell proliferation and apoptosis in two human CRC derived cell lines, HCT15 and CO115, harboring KRAS and BRAF activating mutations, respectively. In KRAS mutated HCT15 cells, Q and L significantly decreased ERK phosphorylation, whereas in BRAF mutated CO115 cells the three compounds decreased Akt phosphorylation but had no effect on phospho-ERK. Our findings show that these natural compounds have antiproliferative and proapoptotic effects and simultaneously seem to act on KRAS and PI3K but not on BRAF. These results shed light on the molecular mechanisms of action of Q, L and UA and emphasize the potential of dietary choices for the control of CRC progression.
Keywords :
Flavonoids , colorectal carcinoma , Ursolic acid , Molecular nutrition , MAPK/ERK and PI3K pathways
Journal title :
Cancer Letters
Serial Year :
2009
Journal title :
Cancer Letters
Record number :
1814054
Link To Document :
بازگشت