Author/Authors :
Gunji، نويسنده , , Yoshio and Tagawa، نويسنده , , Masatoshi and Matsubara، نويسنده , , Hisahiro and Takenaga، نويسنده , , Keizo and Sugaya، نويسنده , , Makoto and Tasaki، نويسنده , , Kentaro and Maeda، نويسنده , , Tomoko and Kondo، نويسنده , , Fukuo and Nakajima، نويسنده , , Kazuaki and Suzuki، نويسنده , , Takao and Asano، نويسنده , , Takehide and Ochiai، نويسنده , , Takenori and Isono، نويسنده , , Kaichi and Sakiyama، نويسنده , , Shigeru، نويسنده ,
Abstract :
We have examined the antitumor effect of murine colon carcinoma cells engineered to produce human interleukin-2 (IL-2) in syngeneic mice. Subcutaneous inoculation of retrovirally-transduced cells with IL-2 gene formed small tumors, but they became regressed spontaneously. Consequently, the inoculated mice showed prolonged survival. Histological examination of the tumors derived from IL-2-producers revealed predominant infiltration of macrophages around tumor necrotic masses. Thus, inoculation of IL-2-producing cells could protect the mice from subsequent subcutaneous or intraperitoneal challenges with wild-type cells, suggesting the induction of acquired immunity due to the effect of tumor vaccination.
Keywords :
Interleukin-2 , Peritoneal dissemination , Gene Therapy , Colon tumor
