Title of article :
Multiple synchronous primaries of the gastrointestinal tract: a molecular case report
Author/Authors :
Herring، نويسنده , , J.Ashley and Shivangi، نويسنده , , Udaya and Hall، نويسنده , , Cathie C. and Mihas، نويسنده , , Anastasios A. and Lynch، نويسنده , , Cynthia and Vijay-Munshi، نويسنده , , Natasha and Hall، نويسنده , , Terrence J.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1996
Abstract :
Six synchronous gastrointestinal primaries were identified in a 70 year old male with no known cancer predisposition syndrome or recognized risk factors except alcohol abuse. These specimens appeared to be independent and unrelated by gross and histopathological examination. In order to further evaluate the six tumors, we analyzed selected DNA sequences for alterations in the K-ras oncogene and p53 tumor suppressor gene. In addition, three loci were analyzed to determine microsatellite instability. Using the polymerase chain reaction, single stranded conformational polymorphism, and DNA sequencing, we demonstrated that each primary manifests genetic characteristics typical of the tissue of origin. In addition, one primary, a moderately differentiated colon adenocarcinoma, exhibited mutations not detected in the other specimens. This study suggests that these synchronous primaries arose independently and progressed along different carcinogenic pathways.
Keywords :
Gastrointestinal tract , Synchronous primaries
Journal title :
Cancer Letters
Journal title :
Cancer Letters