Title of article :
In vitro effects of a recombinant toxin, mSCF-PE40, targeting c-kit receptors ectopically expressed in small cell lung cancers
Author/Authors :
Nishida، نويسنده , , Keiko and Seto، نويسنده , , Masao and Takahashi، نويسنده , , Takashi and Oshima، نويسنده , , Yasuo and Asano، نويسنده , , Shigetaka and Tojo، نويسنده , , Arinobu and Ueda، نويسنده , , Ryuzo، نويسنده ,
Abstract :
Most small cell lung cancers (SCLCs) ectopically express high levels of the c-kit receptor. We have examined if the receptor can serve as a target for a chimeric toxin, mSCF-PE40 composed of murine stem cell factor (SCF) genetically fused to the N terminus of a modified form of Pseudomonas exotoxin (PE) lacking its cell recognition domain. Selective cytotoxicity was found for human c-kit receptor-negative cells. This agent thus warrants further evaluation for therapy of human CSLCs.
Keywords :
Recombinant toxin , C-kit receptor , Small cell lung cancer , Ectopic expression , Stem cell factor , Chimeric toxin
