Author/Authors :
Kubota، نويسنده , , Kengo and Fukamiya، نويسنده , , Narihiko and Tokuda، نويسنده , , Harukuni and Nishino، نويسنده , , Hoyoku and Tagahara، نويسنده , , Kiyoshi and Lee، نويسنده , , Kuo-Hsiung and Okano، نويسنده , , Masayoshi، نويسنده ,
Abstract :
Short-term in vitro assays for tumor promoters and antitumor promoters (Epstein-Barr virus activation test) were carried out for 14 quassinoids isolated from Ailanthus altissima. Some quassinoids, including ailantinol B, ailantinol C, ailanthone, and shinjulactone A, showed moderate activity at a molar ratio of 1:100 (TPA/quassinoids), and the results led to the elucidation of structure-activity relationships.
Keywords :
Epstein-Barr virus activation test , quassinoids , structure-activity relationships , Antitumor promoting effect
