Author/Authors :
Steerenberg، نويسنده , , P.A. and Garssen، نويسنده , , J. and Dortant، نويسنده , , P.M. and van der Vliet، نويسنده , , H. and Geerse، نويسنده , , E. and Verlaan، نويسنده , , A.P.J. and Goettsch، نويسنده , , W.G. and Sontag، نويسنده , , Y. and Bueno-de-Mesquita، نويسنده , , H.B. and Van Loveren، نويسنده , , H.، نويسنده ,
Abstract :
The effects of quercetin (4%) on UVB-induced carcinogenesis and immunosuppression were studied in hairless SKH-1 mice exposed daily to suberythemal UVB for 12/13 and 16/17 weeks. Macroscopic and microscopic examinations showed that quercetin did not affect the onset and growth of UVB-induced non-melanoma skin tumors. Quercetin prevented the UV-induced suppression of the contact hypersensitivity (CHS) and the reduction of the percentage of CD8-positive cells in spleen and lymph nodes. Other immunological parameters were not affected. Thus, the results indicate that oral intake of a high dose of quercetin does not prevent UVB-induced carcinogenesis, although it restores the skin-associated CHS response.
