ANALGESIC ACTIVITY OF 3-[(5-SUBSTITUED) - 1, 3, 4 OXADIAZOLE-2-YL) METHYL AMINO]-2-METHYL QUINAZOLIN-4(3H)-ONES

Heterocyclic chemistry is the branch of chemistry dealing with the synthesis, properties, and applications of heterocyclics. Heterocyclic chemistry comprises at least half of all organic chemistry research worldwide. In particular, heterocyclic structures form the basis of many pharmaceutical, agrochemical and veterinary products.Various novel classes of structurally different quinazolinones have been designed and synthesized depicting potential interventions such as antibacterial, antifungal, antiviral, anticonvulsant, CNS depressant, anti-inflammatory, antihistaminic, anticancer and so on. All the synthesized quinazolinone derivatives were confirmed preliminarily by M.P and TLC and further compounds were screened for analgesic activity using acetyl salicylic acid as standard and the synthesized quinazolinone derivatives showing significant activity & hot-plate latency assay was used for the determining analgesic activity.