Title of article
Targeted chemotherapy in mice with peritoneally disseminated gastric cancer using monoclonal antibody–drug conjugate
Author/Authors
Okamoto، نويسنده , , Kazuma and Yamaguchi، نويسنده , , Toshiharu and Otsuji، نويسنده , , Eigo and Yamaoka، نويسنده , , Nobuki and Yata، نويسنده , , Yoshihiro and Tsuruta، نويسنده , , Hiroshi and Kitamura، نويسنده , , Kazuya and Takahashi، نويسنده , , Toshio، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
231
To page
236
Abstract
The murine monoclonal antibody A7 (MAb A7) is reactive against most human gastric cancer cell lines. Using a nude mouse peritoneal dissemination model of human gastric cancer, we investigated targeted chemotherapy using a conjugate of neocarzinostatin (NCS) with MAb A7 (A7-NCS). After demonstrating cytotoxicity of the complex against the human gastric cancer cell line MKN45 in vitro, we intraperitoneally injected A7-NCS, NCS or saline into nude mice bearing peritoneally disseminated human gastric cancer. A7-NCS inhibited peritoneal dissemination significantly more effectively than NCS. MAb A7 may prove to be an effective carrier for antineoplastic drugs in patients with peritoneal dissemination of gastric cancer.
Keywords
Human gastric cancer , Peritoneal dissemination , Targeting chemotherapy , monoclonal antibody , Conjugate
Journal title
Cancer Letters
Serial Year
1998
Journal title
Cancer Letters
Record number
1816232
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