Author/Authors :
Iniesta، نويسنده , , Pilar and Vega، نويسنده , , Francisco J and Caldés، نويسنده , , Trinidad and Massa، نويسنده , , Mar??a-José and de Juan، نويسنده , , Carmen and Cerd?n، نويسنده , , Francisco and Martin-Sanchez، نويسنده , , Andrés and L?pez، نويسنده , , Jose A and Torres، نويسنده , , Antonio J and Balibrea، نويسنده , , Jose Antonio Donaire Benito، نويسنده , , Manuel، نويسنده ,
Abstract :
We have studied 61 resected colorectal adenocarcinomas in order to investigate p53 mutations as a prognostic factor for this pathology. Mutations in exons 5–9 of the p53 gene were analyzed by the polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) technique followed by sequencing. Our data indicate that p53 exon 7 mutations were prevalent in the latest stages of colorectal carcinogenesis and patients bearing this alteration had the worst prognosis. Therefore, according to our results, mutations affecting exon 7 of the p53 gene could be considered as a useful marker of biological aggressiveness for colorectal cancer.
