Author/Authors :
Ito، نويسنده , , Chihiro and Itoigawa، نويسنده , , Masataka and Furukawa، نويسنده , , Hiroshi and Rao، نويسنده , , K.Sundar and Enjo، نويسنده , , Fumio and Bu، نويسنده , , Ping and Takayasu، نويسنده , , Junko and Tokuda، نويسنده , , Harukuni and Nishino، نويسنده , , Hoyoku، نويسنده ,
Abstract :
To search for possible antitumor promoters, we carried out a primary screening of 20 xanthones isolated from plants of the Guttiferae family, using their possible inhibitory effects on Epstein–Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. Some of these xanthones, namely 1,3,7-trihydroxy-2-(3-methyl-2-butenyl)xanthone (8), dulxanthone-B (10) and latisxanthone-C (15), were observed to significantly inhibit the EBV-EA activation. The investigation indicated that 8, 10 and 15 might be valuable antitumor promoters.
Keywords :
Epstein–Barr virus activation test , Antitumor promoting effect , structure–activity relationships , Xanthones
