Author/Authors :
Murase، نويسنده , , Satoru and Saio، نويسنده , , Masanao and Takenaka، نويسنده , , Katsunobu and Shinoda، نويسنده , , Yong-jun and Nishimura، نويسنده , , Yasuaki and Sakai، نويسنده , , Noboru and Takami، نويسنده , , Tsuyoshi، نويسنده ,
Abstract :
The aim of this study is to determine the diagnostic value of cerebrospinal fluid (CSF) soluble CD27 (sCD27) as a tumor marker for primary central nervous system lymphoma (PCNSL). We examined sCD27 levels in CSF obtained from various types of brain tumor patients. Forty-two patients were studied (including 12 PCNSL patients) who had not received any therapy for their tumors. In all PCNSL cases, CSF sCD27 levels were more than 15 U/ml (median 84.5 U/ml, range 17–484 U/ml) and in other brain tumor cases, CSF sCD27 levels were all less than 15 U/ml. Our data suggest that CSF sCD27 levels are useful to distinguish PCNSL from other brain tumors.
Keywords :
Primary central nervous system lymphoma , Tumor Marker , cerebrospinal fluid , CD27
