Author/Authors :
Silva، نويسنده , , José M. and Garcia-Breijo، نويسنده , , Jose M. Carvajal-Gonzalez، نويسنده , , Rocio and Dominguez، نويسنده , , Gemma and Jareٌo، نويسنده , , Eugenia and Palacios، نويسنده , , Jose and Navarro، نويسنده , , Fatima and Provencia، نويسنده , , Mariano and Espaٌa، نويسنده , , Pilar and Bonilla، نويسنده , , Felix، نويسنده ,
Abstract :
This study was carried out to evaluate the frequencies of alleles of four polymorphic markers in the 17q21 region in breast cancer patients, and their relation to seven pathological parameters. One hundred and sixty-four patients with breast cancer and 102 controls were analyzed. D17S856, D17S855, D17S1323 and D17S1327 polymorphic markers were studied, and used to investigate loss of heterozygosity in this region. The frequencies of alleles at marker D17S856 differed significantly in breast cancer patients and controls, and were related to histologic features considered to indicate a poor prognosis. When present, the pathophenotype of tumors associated with LOH in the 17q21 region is modified.
Keywords :
breast cancer , 17q21 region , LOH , genotypes , Allele frequencies
