Author/Authors :
Altungoz، نويسنده , , Oguz and Meloni، نويسنده , , Aurelia M. and Peier، نويسنده , , Andrea and Zalupski، نويسنده , , Mark and Spanier، نويسنده , , Suzanne and Brooks، نويسنده , , John S.J. and Sandberg، نويسنده , , Avery A.، نويسنده ,
Abstract :
We report the cytogenetic findings in three mixed liposarcoma following short-term cultures. During the course of cytogenetic investigation of various types of liposarcomas, we observed an interstitial deletion of the long arm of chromosome 6 together with the translocation (12;16) (q13;p11) in three tumors. Translocation (12;16) is associated with myxoid and mixed (myxoid/round cell) liposarcomas, although deletion of chromosome 6 has been observed in only a few of these tumors. Our findings suggest that del(6), as an additional change in myxoid liposarcoma, is probably related to tumor progression.
