Author/Authors :
Romani، نويسنده , , M. and Tonini، نويسنده , , G.P. and Banelli، نويسنده , , B. and Allemanni، نويسنده , , G. and Mazzocco، نويسنده , , K. and Scaruffi، نويسنده , , P. G. Boni، نويسنده , , L. and Ponzoni، نويسنده , , M. and Pagnan، نويسنده , , G. and Raffaghello، نويسنده , , L. and Ferrini، نويسنده , , Dawn S. and Croce، نويسنده , , M. and Casciano، نويسنده , , I.، نويسنده ,
Abstract :
The p73 gene is a p53 homologue localized at 1p36.3, a chromosomal region frequently deleted in neuroblastoma. p73 was originally considered an oncosuppressor gene. However, it was soon realized that its mode of action did not resemble that of a classic anti-oncogene. The recent discovery of N-terminal truncated isoforms, with oncogenic properties, showed that p73 has a ‘two in one’ structure. Indeed, the full-length variants are strong inducers of apoptosis while the truncated isoforms inhibit the pro-apoptotic activity of p53 and of the full-length p73.
eview summarizes some aspects of p73 biology with particular reference to its possible role in neuroblastoma.
Keywords :
Neuroblastoma , p73 , Tumor suppressor gene , apoptosis , Methylation
