Title of article :
MEIS homeobox genes in neuroblastoma
Author/Authors :
Geerts، نويسنده , , Dirk and Revet، نويسنده , , Ingrid and Jorritsma، نويسنده , , Gerda and Schilderink، نويسنده , , Nathalie and Versteeg، نويسنده , , Rogier، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
The common pediatric tumor neuroblastoma originates from primitive neural crest-derived precursor cells of the peripheral nervous system. Neuroblastoma especially affects very young children, and can already be present at birth. Its early onset and cellular origin predict the involvement of developmental control genes in neuroblastoma etiology. These genes are indispensable for the tight regulation of normal embryonic development but as a consequence cause cancer and congenital diseases upon mutation or aberrant expression. To date however, the connotation of these genes in neuroblastoma pathogenesis is scant. This review recapitulates data on the MEIS homeobox control genes in cancer and focuses on neuroblastoma.
Keywords :
Signaling network , tale , Signal transduction , MEIS , Neuroblastoma , homeobox
Journal title :
Cancer Letters
Journal title :
Cancer Letters