Author/Authors :
Viniou، Nora نويسنده , , Nora and Yataganas، نويسنده , , Xenophon and Abazis، نويسنده , , Danae and Paterakis، نويسنده , , George and Vavourakis، نويسنده , , Stathis and Stamatopoulos، نويسنده , , Kostas and Matzourani، نويسنده , , Marina and Loukopoulos، نويسنده , , Dimitris and Pangalos، نويسنده , , Constantinos، نويسنده ,
Abstract :
Cytogenetic analysis of bone marrow cells from a patient with anemia, marked leukocytosis with eosinophilia, and thrombocytopenia showed monosomy 7 in all metaphases examined. The patient has refractory anemia (RA) according to FAB classification. Because of the hypereosinophilia of the patient, PCR technique was performed and no bcr-abl mRNA, specific for chronic myelogenous leukemia, was detected. Monosomy 7 has not been previously described in cases with hypereosinophilia. We assume, according to previous reports, that multiple genetic lesions can be involved in the pathogenesis of hypereosinophilia in this patient.
