Title of article :
Reactive oxygen species: Biological stimuli of neuroblastoma cell response
Author/Authors :
Marengo، نويسنده , , Barbara and Raffaghello، نويسنده , , Lizzia and Pistoia، نويسنده , , Vito and Cottalasso، نويسنده , , Damiano and Pronzato، نويسنده , , Maria Adelaide and Marinari، نويسنده , , Umberto Maria and Domenicotti، نويسنده , , Cinzia، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
Reactive oxygen species play a critical role in differentiation, proliferation and apoptosis acting as ‘second messengers’ able to regulate sulphydryl groups in signaling molecules as protein kinase C, a family of isoenzymes involved in many cellular responses and implicated in cell transformation. Neuroblastoma is characterised by the production of oxygen intermediates and l-buthionine-S,R-sulfoximine, a glutathione-depleting agent that has been tested in the clinics, exploits this biological peculiarity to induce cell death. The latter process is mediated by the oxidative activation of PKC delta which might be involved also in the production of reactive oxygen species, thus amplifying the apoptotic cascade.
Keywords :
apoptosis , MYCN amplification , Reactive oxygen species , Neuroblastoma , Protein kinase C
Journal title :
Cancer Letters
Journal title :
Cancer Letters