Author/Authors :
Ariyama، نويسنده , , Takeshi and Inazawa، نويسنده , , Johji and Uemura، نويسنده , , Yoshiki and Kakazu، نويسنده , , Naoki and Maekawa، نويسنده , , Taira and Urase، نويسنده , , Fumiaki and Irimajiri، نويسنده , , Kiyohiro and Horiuchi، نويسنده , , Atsushi and Nakamura، نويسنده , , Yusuke and Abe، نويسنده , , Tatsuo، نويسنده ,
Abstract :
The transient appearance of a Philadelphia chromosome (Ph) negative clone with trisomy 8 was found in the bone marrow cells from a patient with Ph positive CML during the course of a-interferon (IFN) therapy. To determine whether this clone was derived from a Ph positive clone or from some other cell lineage, we performed molecular cytogenetic studies on bone marrow cells from the patient by fluorescence in situ hybridization (FISH). No fusion of BCR-ABL could be detected in cells with trisomy 8, clearly indicating that the Ph negative trisomy 8 clone was not derived from the Ph positive CML population.
