A unique chromosome translocation, t(11;12;18)(q13;q13;q12), in primary lung lymphoma

A 54-year-old man with a primary lung lymphoma of mucosa-associated lymphoid tissue (MALT) origin whose tumor cells had a t(11;12;18)(q13;q13;q12) chromosome abnormality is described. The morphologic, immunologic, and molecular biologic investigations showed that the patientʹs lung tumor consisted of small lymphoid cells that expressed monoclonal IgM, K-type immunoglobulin, and immunoglobulin gene (JH and CK) rearrangements. Cytogenetic study revealed that the tumor cells contained a unique chromosome translocation, t(11;12;18) (q13;q13;q12), that has not been reported previously in lymphoma.