Author/Authors :
Cigudosa، نويسنده , , J.C. and Pedrosa Guerra، نويسنده , , A. and Otero Gَmez، نويسنده , , A. and Carrasco Juan، نويسنده , , J.L. and Pérez Gomez، نويسنده , , J.A. and Ferrer Roca، نويسنده , , O. and Garcia Miranda، نويسنده , , J.L.، نويسنده ,
Abstract :
We describe the cytogenetics of a multinodular thyroid goiter where 90% of the analyzed cells showed a diploid karyotype with a balanced translocation between chromosomes 5 and 19: 46,XX,t(5;19)(q13;q13). This translocation has been previously described in cases of thyroid adenoma. Our case is the first report of this anomaly in nodular hyperplasia. We discuss its putative role in the neoplastic transformation of thyroid lesions.
