Translocational rearrangements of 11823 in acute monoblastic leukemia

We report the rearrangements of 11823 in the form of t(6;11)(q27;q23) and t(11;16)(q23;q24) in three cases of acute monoblastic leukemia. The former translocation had only previously been reported in five cases of acute myeloid leukemia, while the latter is hitherto undescribed. In addition to describing a new chromosomal locus 16824, which may participate in translocational exchanges with 11q23, this report also confirms the close association between 11823 rearrangement and the involvement of the monocytic lineage in acute myeloid leukemia.