Author/Authors :
Look، نويسنده , , Rogan Mon and Lim، نويسنده , , Stephen Wong and Schreck، نويسنده , , Rhona Rebecca and Lee، نويسنده , , Stephen and Fuerst، نويسنده , , Marie Perrelli and Lawrence، نويسنده , , Grace Natividad and Kusuanco، نويسنده , , Donato Absalom and Kessler، نويسنده , , Christine Elisabeth and Giles، نويسنده , , Francis Joseph، نويسنده ,
Abstract :
The prevalance of chromosomal abnormalities in multiple myeloma (MM) has been difficult to detect by karyotyping primarily because of the low proliferative rate of malignant plasma cells. The reported incidences of abnormal karyotypes range from 24% to 63% in bone marrows obtained from MM patients, with the higher rates being seen in aggressive disease [1–8]. Detection of abnormal karyotypes in MM has been associated with a poor prognosis. We report a MM patient with an 8;22 Burkitt translocation, the first such reported case.
