Author/Authors :
Yuki، نويسنده , , Kanako and Natsume، نويسنده , , Atsushi and Yokoyama، نويسنده , , Hidenori and Kondo، نويسنده , , Yutaka and Ohno، نويسنده , , Masasuke and Kato، نويسنده , , Takenori and Chansakul، نويسنده , , Phassarin and Ito، نويسنده , , Motokazu and Kim، نويسنده , , Seung-Up and Wakabayashi، نويسنده , , Toshihiko، نويسنده ,
Abstract :
The response of cancer patients to interferon (IFN) treatment is long-lasting, indicating that IFN may act on small cancer stem cell populations. Glioma-initiating cells (GICs) can self-renew and induce the formation of heterogeneously differentiated tumor cells and are resistant to chemotherapeutic agents like temozolomide. In this study, we showed that via STAT3 signaling, IFN-β suppressed the proliferation, self-renewal, and tumorigenesis of GICs, induced their terminal differentiation to mature oligodendroglia-like cells, and exhibited synergistic cytotoxicity with temozolomide. Therefore, IFN may be a potential therapeutic agent for inducing the terminal differentiation of GICs.
Keywords :
Interferon , Glioma-initiating cells , Oligodendrogenesis , Differentiation
