Author/Authors :
Li، نويسنده , , Mengsen and Li، نويسنده , , Hui and Li، نويسنده , , Chaoying-Christine Guo، نويسنده , , Liyuan and Liu، نويسنده , , Han and Zhou، نويسنده , , Sheng and Liu، نويسنده , , Xinhua and Chen، نويسنده , , Zhuo and Shi، نويسنده , , Shuanglin and Wei، نويسنده , , Jiang and McNutt، نويسنده , , Michael A. and Li، نويسنده , , Gang، نويسنده ,
Abstract :
The role of AFP in the retinoic acid-RAR signaling pathway was investigated in human hepatoma Bel 7402 cells. The results showed that AFP and RAR-β were co-localized and interacted in cytoplasm. AFP may inhibit translocation of RAR-β into the nucleus via competitive binding to RAR-β with ATRA, which was reversed by AFP-siRNA transfection. Our data suggest that the ATRA resistance of Bel 7402 cells is at least in part attributable to their high level of cytoplasmic AFP. Thus, by counteracting the effect of AFP, it may be possible to increase the sensitivity of tumor cells to ATRA.
Keywords :
Alpha-fetoprotein , Hepatoma , Nuclear receptor , All trans retinoic acid , apoptosis
