Author/Authors :
Kim، نويسنده , , Ran-Ju and Kim، نويسنده , , Soo-Rim and Roh، نويسنده , , Kyung Jin and Park، نويسنده , , Sang-Bum and Park، نويسنده , , Jeong-Ran and Kang، نويسنده , , Kyung-Sun and Kong، نويسنده , , Gu-Sheng Tang ?، نويسنده , , Binwu and Yang، نويسنده , , Yu-an and Kohn، نويسنده , , Ethan A. and Wakefield، نويسنده , , Lalage M. and Nam، نويسنده , , Jeong-Seok، نويسنده ,
Abstract :
The cancer stem cell (CSC) hypothesis proposes that CSCs are the root of cancer and cause cancer metastasis and recurrence. In this study, we examined whether Ras signaling is associated with stemness of the CSCs population characterized by the stem cell antigen (Sca-1) phenotype in a 4T1 syngeneic mouse model of breast cancer. The Sca-1pos putative CSCs had high levels of activated Ras and phosphorylated MEK (p-MEK), compared with counterparts. The Ras farnesylation inhibitor (FTI-277) suppressed the maintenance and expansion of CSCs. Therefore, selective inhibition of Ras activation may be useful for stem-specific cancer therapy.
