Author/Authors :
Martيn، نويسنده , , Vanesa and Garcيa-Santos، نويسنده , , Guillermo and Rodriguez-Blanco، نويسنده , , Jezabel and Casado-Zapico، نويسنده , , Sara and Sanchez-Sanchez، نويسنده , , Ana and Antolيn، نويسنده , , Isaac and Medina، نويسنده , , Maria and Rodriguez، نويسنده , , Carmen، نويسنده ,
Abstract :
Despite the common expression of death receptors, many types of cancer including gliomas are resistant to the death receptor ligand (TRAIL). Melatonin antitumoral actions have been extensively described, including oncostatic properties on several tumor types and improvement of chemotherapeutic regimens. Here, we found that melatonin effectively increase cell sensitivity to TRAIL-induced cell apoptosis in A172 and U87 human glioma cells. The effect seems to be related to a modulation of PKC activity which in turns decreases Akt activation leading to an increase in death receptor 5 (DR5) levels and a decrease in the antiapoptotic proteins survivin and bcl-2 levels.
Keywords :
TRAIL , apoptosis , Death receptors , Glioma , melatonin
