Title of article
Genomic gain of 5p15 leads to over-expression of Misu (NSUN2) in breast cancer
Author/Authors
Frye، نويسنده , , Michaela and Dragoni، نويسنده , , Ilaria and Chin، نويسنده , , Suet-Feung and Spiteri، نويسنده , , Immaculada and Kurowski، نويسنده , , Agata and Provenzano، نويسنده , , Elena and Green، نويسنده , , Andrew and Ellis، نويسنده , , Ian O. and Grimmer، نويسنده , , Donna and Teschendorff، نويسنده , , Andrew and Zouboulis، نويسنده , , Christos C. and Caldas، نويسنده , , Carlos and Watt، نويسنده , , Fiona M.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2010
Pages
10
From page
71
To page
80
Abstract
We have examined expression of the Myc target gene Misu (NSUN2) in breast cancer. There was extensive copy number gain, and increased mRNA and protein levels, of Misu in approximately one third of breast cancer cell lines and primary tumours examined, irrespective of tumour subtype. Genes on 5p15.31-33, where Misu is located, showed evolutionary synteny. siRNA-mediated knockdown of Misu reduced cell number in over half of the cell lines tested, irrespective of estrogen receptor status. We conclude that Misu is up-regulated in a substantial proportion of breast cancers and has therapeutic potential as a drug target.
Keywords
RNA methyltransferase , MYC , gene amplification , breast cancer
Journal title
Cancer Letters
Serial Year
2010
Journal title
Cancer Letters
Record number
1818294
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