Author/Authors :
Okamura، نويسنده , , Yukiyasu and Nomoto، نويسنده , , Shuji and Kanda، نويسنده , , Mitsuro and Li، نويسنده , , Qiyong and Nishikawa، نويسنده , , Yoko and Sugimoto، نويسنده , , Hiroyuki and Kanazumi، نويسنده , , Naohito and Takeda، نويسنده , , Shin-ichi Nakao، نويسنده , , Akimasa، نويسنده ,
Abstract :
Hepatocellular carcinoma (HCC) is one of the world’s top five causes of cancer-related deaths and treatment options are limited in this type of cancer. In the present study, we attempt to identify the novel suppressor genes of HCC using a double-combination array we designed. Leukemia inhibitory factor receptor (LIFR) is one of suppressor genes using this method. We found that 23 of 48 (47.9%) tumor tissues showed promoter hypermethylation of LIFR gene, and the expression level was clearly reduced in tumor tissues (P < 0.0001). The present study suggests that our method is a meaning technique able to detect novel genes and that LIFR gene is a new suppressor gene of HCC.
Keywords :
hepatocellular carcinoma , Tumor suppressor gene , Expression array , Leukemia inhibitory factor receptor , Single nucleotide polymorphism array
